An Experiment Is Performed in Which a Point Mutation Is

question 1

Multiple Choice

An experiment is performed in which a point mutation is introduced randomly into the Zap-70 gene for a particular strain of mice. The mutant mice display a defect in T cell development. However, precursor T cells isolated from the thymus of these mice show normal expression levels of Zap-70 of the correct molecular weight. On further in vitro analysis, the mutant Zap-70 is found to bind to ITAM motifs in the cytoplasmic tail of the chain, but only when the chain is phosphorylated. No phosphorylated LAT is detected, however. Given these data, in which of the following protein domains is the mutation most likely to be present?

• A)Pleckstrin homology (P
• H) domain
• B)Proline-rich (P
• R) domain
• C)SH1 domain
• D)SH2 domain
• E)SH3 domain

---

Definitions:

Computer Software Engineers

Professionals who apply engineering principles to design, develop, test, and evaluate software and systems that enable computers to perform their applications.

Productivity

A measure of the efficiency of production, often quantified as the ratio of output to inputs in the production process.

Laser Printers

Devices that use laser technology to produce high-quality text and graphics on paper.

Marginal Revenue Product

The additional revenue generated from using one more unit of a factor of production, used to determine the optimal level of resource allocation.