Transgenic Mouse Lines Have Been Very Useful for the Study

question 11

Multiple Choice

Transgenic mouse lines have been very useful for the study of mechanisms of self-tolerance.In one such line,transgenes were introduced encoding a T cell receptor (TCR) specific for the H-Y antigen,which is a protein expressed by many cell types only in male mice.When these transgenic mice were analyzed,researchers found that T cells expressing the H-Y-specific TCR developed normally in female mice but not in male mice.This finding illustrates which of the following mechanism of self tolerance?

• A)Peripheral anergy
• B)Central (thymic)deletion
• C)Clonal ignorance
• D)Regulatory T cell-mediated suppression
• E)Peripheral deletion

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Definitions:

Migration

The movement of people or animals from one region to another, often cyclically or seasonally.

Adenocarcinoma

A type of cancer that forms in mucus-secreting glands throughout the body.

Astrocytoma

A type of brain tumor that originates in astrocytes, which are star-shaped cells in the central nervous system.

Carcinogen

A substance capable of causing cancer in living tissue.