How Might a Single Base Substitution in the Sequence of a Gene

question 23

Multiple Choice

How might a single base substitution in the sequence of a gene affect the amino acid sequence of a protein encoded by the gene,and why?

• A)Only a single amino acid could change,because the reading frame is unaffected.
• B)The amino acid sequence would be substantially altered,because the reading frame would change with a single base substitution.
• C)All amino acids following the substitution would be affected,because the reading frame would be shifted.
• D)It is not possible for a single base substitution to affect protein structure,because each codon is three bases long.

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