Use the Following Information When Answering the Corresponding Question(s)

question 7

Multiple Choice

Use the following information when answering the corresponding question(s) .
Shu-ichi Nakano reported in Science in February 2000 that "The RNA enzyme (ribozyme) from hepatitis delta virus catalyzes self-cleavage of a ...[chemical] ...bond." This reaction is inherently slow due to the formation of an unfavorable negative charge on the ribozyme.The author goes on to show that this self-cleavage is made faster by joining it with an acid-base reaction that neutralizes the negative charge.Nakano's model describes a positively charged cytosine base on the ribozyme acting as the acid,and magnesium hydroxide acting as the base.Specifically,the cytosine donates its proton (H⁺) to neutralize the unstable negative charge that would have formed on the ribozyme.
-Refer to Nakano's quote.What can be inferred about the free-energy profile for the self-cleavage reaction from the information provided in the paragraph?

• A)It must be endergonic.
• B)It must be exergonic.
• C)It must be endothermic.
• D)It must be exothermic.

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