When Calculating the Recurrence Risk for a Complex, Possibly Polygenic

question 1

Multiple Choice

When calculating the recurrence risk for a complex, possibly polygenic disorder with a couple who already have one child with the disorder, which additional factorhasthe greatest impact on increasing this risk?

• A)The child with the disorder is male, and the overall incidence of the disorder is twice as high in males than females.
• B)Both the mother and the father are heavily exposed to a variety of chemicals in their workplaces.
• C)The father has a nephew with a mild form of the same disorder.
• D)The mother has a brother who also has the same disorder.

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Definitions:

SAM

S-Adenosylmethionine, a compound involved in methyl group transfers in biological processes.

Biological Systems

Complex networks of biotic and abiotic components that interact in precisely balanced ways within living organisms.

Sulfonium Salt

An ionic compound featuring a central sulfur atom covalently bonded to three organic groups and bearing a positive charge, with an associated anion to balance the charge.

Major Organic Product

The leading chemical substance formed with the utmost output in an organic reaction.