You Are Caring for a Child with Acute Lymphoblastic Leukemia

question 6

Multiple Choice

You are caring for a child with acute lymphoblastic leukemia. She has been genotyped and is homozygous for a TPMT polymorphism, producing very little of the enzymeneeded for this drug's metabolism. How would you expect this to affect dosing of the drug 6-mercaptopurine?

• A)This child should receive only a small fraction of the standard dose.
• B)This child should receive the drug intravenously rather than orally.
• C)This child should receive higher doses than the standard dose.
• D)This child should receive the standard dose.

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