Use the Following Information to Answer the Following Questions

question 5

Multiple Choice

Use the following information to answer the following questions.
CML (chronic myelogenous leukemia) results from a translocation between human chromosomes 9 and 22. The resulting chromosome 22 is significantly shorter than the usual, and it is known as a Philadelphia (Ph') chromosome. The junction at the site of the translocation causes over-expression of a thymine kinase receptor. A new drug (Gleevec or imatinib) has been found to inhibit the disease if the patient is treated early.
-Which of the following would be a reasonably efficient technique for confirming the diagnosis of CML?

• A)searching for the number of telomeric sequences on chromosome 22
• B)looking for a Ph' chromosome in a peripheral blood smear
• C)enzyme assay for thymine kinase activity
• D)FISH study to determine the chromosomal location of all chromosome 22 q fragments
• E)identification of the disease phenotype in review of the patient's records

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Definitions:

Degrees of Freedom

In statistics, it refers to the number of independent values or quantities which can be assigned to a statistical distribution, less the number of parameters estimated.

Chi-Square

A statistical test used to assess the differences between categorically grouped data by comparing the observed frequencies of groups with expected frequencies derived from a hypothesis.

Row Variable

A variable that constitutes the basis for organizing data in rows in a table or matrix, often used in cross-tabulation.

Column Variable

A variable represented in one of the vertical columns of a data table, often used in multivariate analysis and cross-tabulations.