Use the Following Information to Answer the Next Few Questions

question 41

Multiple Choice

Use the following information to answer the next few questions.
CML (chronic myelogenous leukemia) results from a translocation between human chromosomes 9 and 22. The resulting chromosome 22 is significantly shorter than usual, and it is known as a Philadelphia (Ph') chromosome. The junction at the site of the translocation causes overexpression of a thymine kinase receptor. A new drug (Gleevec or imatinib) has been found to inhibit the disease if the patient is treated early.
-Why would Gleevec most probably cause remission of the disease?

• A) It reverses the chromosomal translocation.
• B) It eliminates the Ph' chromosome.
• C) It removes Ph'-containing progenitor cells.
• D) The drug inhibits the replication of the affected chromosome.
• E) The drug inhibits the specific thymine kinase receptor.

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Growth-Need Individuals

People who are motivated by an inherent desire for personal development and self-improvement.

Job Characteristics Model

A framework identifying five core job dimensions (skill variety, task identity, task significance, autonomy, and feedback) that influence motivational potential and job satisfaction.

Core Job Characteristics

Fundamental attributes of a job that affect an individual's level of satisfaction and motivation, such as skill variety, task significance, and autonomy.

Job Characteristics Model

A theory that suggests jobs can be designed to enhance employee motivation, satisfaction, and performance by incorporating five core job dimensions.