Use the Following Information to Answer the Next Few Questions

question 30

Multiple Choice

Use the following information to answer the next few questions.
Poliovirus is a positive-sense RNA virus of the picornavirus group. At its 5' end, the RNA genome has a viral protein (VPg) instead of a 5' cap. This is followed by a nontranslated leader sequence, and then a single long protein coding region (~7000 nucleotides) , followed by a poly-A tail. Observations were made that used radioactive amino acid analogues. Short-period use of the radioactive amino acids result in labelling of only very long proteins, while longer periods of labelling result in several different short polypeptides.
-What conclusion is most consistent with the results of the radioactive labelling experiment?

• A)The host cell cannot translate viral protein with the amino acid analogues.
• B)Host cell ribosomes only translate the viral code into short polypeptides.
• C)The RNA is only translated into a single long polypeptide, which is then cleaved into shorter ones.
• D)The RNA is translated into short polypeptides, which are subsequently assembled into large ones.
• E)The large radioactive polypeptides are coded by the host, whereas the short ones are coded for by the virus.

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