Naive CD8⁺ T Cells Require Signals in Addition to T

question 10

Multiple Choice

Naive CD8⁺ T cells require signals in addition to T cell receptor recognition of peptide-MHC to become activated and differentiate into cytolytic T cells.These signals are called costimulatory signals and are provided by professional antigen-presenting cells (APCs) ,such as dendritic cells.If a virus infects epithelial cells in the respiratory tract but does not infect professional APCs,what process ensures that naive T cells specific for viral antigens will become activated?

• A)Cross-reactivity,whereby the naive CD8⁺ T cell recognizes a self antigen that is structurally similar to a viral antigen presented by dendritic cells
• B)Crossover,whereby part of the viral genome is exchanged with part of one chromosome of the host
• C)Crosstalk,whereby signals generated by the virus binding to class I MHC molecules intersect with T cell receptor signaling pathways
• D)Cross-presentation,whereby infected epithelial cells are captured by dendritic cells,and the viral proteins originally synthesized in the epithelial cells are processed and presented in association with class I MHC molecules on the dendritic cell
• E)Cross-dressing,whereby viral infection of the epithelial cell stimulates the expression of surface molecules that are typically found only on dendritic cells

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