Which One of the Following Statements About T Cell Tolerance

question 1

Multiple Choice

Which one of the following statements about T cell tolerance to self proteins is accurate?

• A)Self proteins are not presented by the class I pathway because only microbial proteins,and not self proteins,are ubiquinated in the cytosol.
• B)Peptides derived from self proteins are not presented by the class I or class II pathways because MHC molecules are expressed only in response to infections.
• C)Self proteins are not presented by the class II pathway because endosomal acidic proteases digest microbial proteins but not eukaryotic proteins.
• D)Self peptide/self MHC complexes are formed and displayed by antigen-presenting cells in both class I and class II MHC pathways,but T cells that recognize these complexes usually are not present or are functionally inactive.
• E)Peptides derived from self proteins are not displayed by MHC molecules because they usually are displaced by the more abundant microbial peptides.

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