A 2-Year-Old Boy Suffers from Recurrent Bacterial Infection of His

question 19

Multiple Choice

A 2-year-old boy suffers from recurrent bacterial infection of his ears,sinuses,lungs,and skin;laboratory studies indicate absence of sialylated Lewis X on his leukocytes.He is diagnosed with leukocyte adhesion deficiency type 2 (LAD-2) .Which type of adhesive interaction required for leukocyte migration is defective in this boy?

• A)E-selectin ligand binding to E-selectin
• B)CD4 binding to class II MHC
• C)VLA-4 binding to VCAM-1
• D)Ig Fc receptor binding to Ig-coated cells
• E)LFA-1 binding to ICAM-1

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Definitions:

Bonferroni Criterion

A statistical correction method used to address the problem of multiple comparisons by lowering the threshold for statistical significance.

Substantial Bias

An evident prejudice or tendency that significantly affects the outcome of a study or analysis.

Underspecified Models

Models that do not have enough predictors or independent variables to adequately model the observed outcomes or responses.

Underspecified Model

An underspecified model is when a statistical model lacks enough parameters to accurately capture the underlying data structure or dynamics of the dataset.