Which of the Following Mechanisms Contributes to the Change from B

question 8

Multiple Choice

Which of the following mechanisms contributes to the change from B cell production of membrane Ig to secreted Ig?

• A)V(D)J recombinase-mediated deletion of the exon encoding the transmembrane domain
• B)Alternative processing of primary RNA transcripts to remove the transmembrane domain and include a secretory tail piece
• C)Increased vesicular exocytosis of intracellular stores of the secretory form of Ig
• D)Switch recombinase-mediated recombination of the heavy chain locus to juxtapose the V(D)J segment with the exon encoding a secretory tail piece
• E)Up-regulation of ectoenzymes that proteolytically cleave membrane Ig heavy chains just proximal to the membrane

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