Now That Small Molecular-Level Deletions and Subtle Chromosomal Rearrangements Can

question 30

Essay

Now that small molecular-level deletions and subtle chromosomal rearrangements can be discovered using advanced cytogenetic techniques and microarrays,disorders whose causes had not previously been known can have their basis identified.However,since most of these are not widely publicized,being individually rare,it has been difficult to identify patients with shared chromosomal abnormalities who share phenotypic features.A new database,known as DECIPHER,is now available to search for patients with like phenotypes and/or like chromosomal abnormalities.If you are the clinical geneticist who has a patient whose data is entered into this database,suggest three or more ways in which this could be useful either to you or to the patient.

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Definitions:

Capital Accounts

Ledger accounts that show the investment amounts of owners or shareholders in a company.

Loss On Realization

occurs when the proceeds from selling an asset or settling a liability are less than the carrying amount on the books.

Noncash Assets

Assets that cannot be easily converted into cash, such as real estate, equipment, and investments.

Capital Balances

The amount of money each partner has invested in a partnership or the equity value in partnerships' accounts.