Instead of a 5' Cap on the Viral Genomic RNA

question 26

Essay

Instead of a 5' cap on the viral genomic RNA, genomes of the picornaviruses have a covalently bound protein.In addition, the viral 3C protease cleaves a major component of the cap binding complex.This situation should inhibit translation initiation of the picornaviral RNA into protein.Explain how the virus "solves" this problem.

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