Explain Why ATP-Powered Proton Pumps Cannot by Themselves Acidify the Lumen

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The Answer is The V-class proton pump responsible for acidifying the lumen of the lysosome,where the net movement of electric charge occurs during transport,is electrogenic.As each proton is pumped into the lumen,it leaves behind a negatively charged ion in the cytosol.Positive and negative ions attract each other across the membrane of the lysosome,which causes an electric potential.Soon,pumping leads to a buildup of protons in the lumen,which repels other protons.At this point,a significant transmembrane proton concentration gradient cannot be established.Thus,to generate an acidic environment necessary to breakdown components imported into the lysosome,proton transport must be accompanied by an equal number of anions,in this case in the form of Cl-,into the lumen.

Explain Why ATP-Powered Proton Pumps Cannot by Themselves Acidify the Lumen

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