An SH2-Containing Protein Contains a Mutation That Changes Its Binding

question 35

Multiple Choice

An SH2-containing protein contains a mutation that changes its binding pocket such that tyrosine and phosphotyrosine bind with equal affinity.As a result,MEK activity:

• A)decreases due to changes in Raf activation.
• B)decreases due to allosteric inhibition of SH2-domain binding.
• C)increases with ligand binding-induced dimerization.
• D)does not change with receptor dimerization and transautophosphorylation.

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Definitions:

Companionship

The feeling or state of having a friend or partner to share one's activities, life, or experiences with.

Widows

Women who have lost their spouses through death and have not remarried.

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Males who are widowed and have not entered into another marriage.

Congenial Siblings

Brothers and sisters who share a close, friendly, and amicable relationship, often characterized by mutual support and understanding.