Using a Luciferase Reporter System in Tissue Culture Cells,researchers from the University

question 43

Essay

Using a luciferase reporter system in tissue culture cells,researchers from the University of California,San Francisco,found that ethanol stimulates transcription of genes in brain cells possibly involved in the adaptive responses to alcohol.This process was found to depend on PKA activation.By analogy to other PKA-dependent transcription activation pathways,describe a possible pathway for this transcription induction.What other proteins would be involved?

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Definitions:

Receptor Proteins

Proteins located on cell surfaces or within cells that bind specific molecules, triggering various cellular responses.

Hormones

Chemical messengers produced by glands in the endocrine system, affecting various processes in the body like growth and metabolism.

Enzymes

Biological molecules that significantly speed up the rate of virtually all of the chemical reactions that take place within cells.

Plasmodesmata

Channels in plant cell walls that enable communication and transport between cells.