Why Are Two "Hits" Required to Inactivate Tumor Suppressor Genes

question 1

Multiple Choice

Why are two "hits" required to inactivate tumor suppressor genes?

• A) Because each allele must be altered and each person has two copies,or alleles,of each gene,one from each parent
• B) Because the first "hit" stops tissue growth and the second "hit" is needed to cause abnormal tissue growth
• C) Because they are larger than proto-oncogenes requiring two "hits" to effect carcinogenesis
• D) Because the first "hit" is insufficient to cause sufficient damage to cause a mutation

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