Which of the Following Is a Description Consistent with Chronic

question 43

Multiple Choice

Which of the following is a description consistent with chronic myelogenous leukemia (CML) ?

• A) There are defects in the ras oncogene,p53 tumor suppressor gene,and INK4A,the gene encoding a cell-cycle regulatory protein.
• B) The bone marrow and peripheral blood are characterized by leukocytosis and a predominance of blast cells.As the immature blasts increase,they replace normal myelocytic cells,megakaryocytes,and erythrocytes.
• C) There is failure of B cells to mature into plasma cells that synthesize immunoglobulins.
• D) The translocation of genetic material from genes 9 and 22 create an abnormal,fused gene identified as BCR-ABL.

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