Why Is the Most Damage to the Brains of Huntington

question 57

Multiple Choice

Why is the most damage to the brains of Huntington disease patients observed in the striatum?

• A) The Rhes protein, needed for mutant huntingtin to become toxic, is only produced in the striatum.
• B) The huntingtin gene is only expressed in the striatum.
• C) The mutant huntingtin protein becomes toxic when bound to the Rhes protein, which is abundant in the striatum.
• D) Only the cells of the striatum contain the huntingtin mutation.
• E) The CAG expansions are corrected in regions of the brain other than the striatum.

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