Cyclooxygenase 2 Is Expressed Primarily as Part of the Inflammatory

question 10

Essay

Cyclooxygenase 2 is expressed primarily as part of the inflammatory response, whereas cyclooxygenase 1 is expressed more generally. Celecoxib (Celebrex) was designed to target COX2 and is used to reduce inflammation due to arthritis. What structural feature of Celecoxib (Celebrex) makes this drug more selective for COX2 instead of COX1?

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Definitions:

Psychosocially Informed

An approach that considers both psychological and social factors in understanding or addressing issues.

Traditional Classification

A method of organizing or categorizing based on long-established customs, practices, or criteria.

Organic

Refers to substances, practices, or systems that are based on living processes, especially in agriculture, or compounds containing carbon.

Functional

Serving a purpose, or capable of performing or operating according to a specific function or purpose.