Why Do First-Generation Antihistaminics Require Repeated Administration Multiple Times a Day

question 17

Multiple Choice

Why do first-generation antihistaminics require repeated administration multiple times a day?

• A) Smaller doses at a higher frequency will prevent a fatal toxicity.
• B) Absorption in the intestines is slow and often incomplete.
• C) These drugs are rapidly metabolized by the liver.
• D) Renal elimination of these drugs is very quick.

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