Which of the Following Is Not a Component of Knudson's

question 1

Multiple Choice

Which of the following is not a component of Knudson's "two hit" hypothesis?

• A) In the inherited cases of retinoblastoma, one of the inactivating mutations has been transmitted through the germ line.
• B) Two mutational "hits" are required to knock out a gene that normally functions to suppress tumor formation.
• C) A cancer develops only if a second mutation occurs in the somatic cells and if this mutation knocks out the function of the wild-type allele of the tumor suppressor gene.
• D) All of these are true.
• E) None of these are true.

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