Which of the Following Is Not a Component of Knudson's

question 1

Multiple Choice

Which of the following is not a component of Knudson's "two hit" hypothesis?

• A) In the inherited cases of retinoblastoma, one of the inactivating mutations has been transmitted through the germ line.
• B) Two mutational "hits" are required to knock out a gene that normally functions to suppress tumor formation.
• C) A cancer develops only if a second mutation occurs in the somatic cells and if this mutation knocks out the function of the wild-type allele of the tumor suppressor gene.
• D) All of these are true.
• E) None of these are true.

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Definitions:

SAE Standard

Specifications and guidelines for automotive engineering set by the Society of Automotive Engineers.

Kingpins

Essential components in vehicle steering systems that serve as the pivot point for steering knuckles, enabling wheels to turn.

Transverse

Acting in a crosswise direction; for example, an axle on a truck is transversely mounted. Used to describe components (transverse torque rod), positioning (transverse mounted engine), or forces acting on a chassis.

Longitudinal

Refers to something that is oriented or extends in the direction of the length of an object or an entity.