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In a Certain Community,a Mutant Allele for Tay-Sachs Disease Is

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In a certain community,a mutant allele for Tay-Sachs disease is prevalent.This mutation removes a Hind III restriction site in the gene sequence.A probe is available for this region,with the following homology:
 In a certain community,a mutant allele for Tay-Sachs disease is prevalent.This mutation removes a Hind III restriction site in the gene sequence.A probe is available for this region,with the following homology:    Two couples in this community are expecting children.Each couple has a DNA test to determine if their child will have Tay-Sachs.The results of the Southern blot,probed for the region described above is shown below.  \begin{array} {cccccc }  \text { M1 } & \text { F1 } & \text { Child 1 } & \text { M2 } & \text { F2 } & \text { Child 2 } \\\end{array}\\ \begin{array} { | l l l l l l | }  \hline \underline{\quad\quad} &\underline{\quad\quad} & \underline{\quad\quad} & \underline{\quad\quad}& \underline{\quad\quad} & \underline{\quad\quad}\\ \underline{\quad\quad}&\underline{\quad\quad} & & \underline{\quad\quad} & \underline{\quad\quad} & \underline{\quad\quad} \\  \hline \end{array}    Using these results,how would you counsel the couples?
Two couples in this community are expecting children.Each couple has a DNA test to determine if their child will have Tay-Sachs.The results of the Southern blot,probed for the region described above is shown below.
 M1  F1  Child 1  M2  F2  Child 2 \begin{array} {cccccc } \text { M1 } & \text { F1 } & \text { Child 1 } & \text { M2 } & \text { F2 } & \text { Child 2 } \\\end{array}\\\begin{array} { | l l l l l l | } \hline \underline{\quad\quad} &\underline{\quad\quad} & \underline{\quad\quad} & \underline{\quad\quad}& \underline{\quad\quad} & \underline{\quad\quad}\\\underline{\quad\quad}&\underline{\quad\quad} & & \underline{\quad\quad} & \underline{\quad\quad} & \underline{\quad\quad} \\ \hline\end{array}

Using these results,how would you counsel the couples?

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Definitions:

Palliative Care Competencies

The essential skills and knowledge required for healthcare professionals to provide compassionate and effective care to patients with life-limiting illnesses.

Difficult Conversations

Dialogues that are challenging due to the sensitive, controversial, or emotional subject matter involved, often requiring careful navigation and communication skills.

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A medical prognosis indicating that an illness or disease will likely lead to the patient's death within a short period.

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Stressful life events are significant occurrences that can cause psychological stress, potentially impacting an individual's mental and physical health.

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