Mutations Within the Oca2 Gene Are Associated with Albinism and Blindness

question 28

Essay

Mutations within the Oca2 gene are associated with albinism and blindness in cavefish,while mutations in MC1R have been associated with increased pigmentation in the hairs of some pocket mice.With regard to protein function,compare the mutations generating each alteration of phenotype.

---

Definitions:

Z-statistic

A type of standard score that indicates how many standard deviations an element is from the mean, used in significance testing.

Significance Level

A threshold for determining whether a p-value indicates a statistically significant result, usually set at 0.05 (5%).

Nonparametric Tests

Statistical tests that do not assume a specific distribution for the data, making them suitable for analyzing ordinal data or when the assumptions for parametric tests are not met.

Nonparametric Statistical Methods

Statistical methods that do not assume a specific distribution for the data, often used when data doesn't meet the assumptions required for parametric tests.