Which of the Following Sequence of Events Best Explains the Formation

question 5

Multiple Choice

Which of the following sequence of events best explains the formation of carbamate in the mechanism of carbamoyl phosphate synthetase?

• A)Bicarbonate and ATP form carboxyphosphate, then NH₃ performs a nucleophilic attack on carboxyphosphate to form carbamate
• B)Bicarbonate is attacked by NH₃ to produce carbamate with ATP hydrolysis occurring solely to drive the reaction to completion
• C)Bicarbonate reacts with ATP forming carboxy adenylate and pyrophosphate, then NH₃ performs a nucleophilic attack on carboxy adenylate to form carbamate
• D)NH₃ reacts with ATP, which then reacts with bicarbonate followed by loss of phosphate to produce carbamate
• E)none of the above

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