Give the First Step for the Mechanism for Serine Protease

question 66

Multiple Choice

Give the first step for the mechanism for serine protease.

• A)Histidine functions as a base ,increasing the nucleophilicity of serine,which attacks the carbonyl group.
• B)The tetrahedral complex collapses,expelling the amino group.
• C)Water attacks the acyl group of the acyl-enzyme intermediate.
• D)The tetrahedral intermediate collapses,expelling serine.
• E)The negatively charged oxygen hydrogen bonds with two peptide bonds.

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