When Calculating the Recurrence Risk for a Complex, Possibly Polygenic

question 1

Multiple Choice

When calculating the recurrence risk for a complex, possibly polygenic disorder with a couple who already have one child with the disorder, which additional factorhasthe greatest impact on increasing this risk?

• A)The child with the disorder is male, and the overall incidence of the disorder is twice as high in males than females.
• B)Both the mother and the father are heavily exposed to a variety of chemicals in their workplaces.
• C)The father has a nephew with a mild form of the same disorder.
• D)The mother has a brother who also has the same disorder.

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