The Glutamate Side Chain in the Active Site of HMG-CoA

question 16

Multiple Choice

The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after

• A) the mevalonate binds to the active site.
• B) the hydride from the second NADPH attacks the carbonyl center of the aldehyde.
• C) a conformational change triggers the exchange of NADP⁺ for NADPH.
• D) CoA is reduced to CoA-SH.

---

Definitions:

Community Health

The branch of public health focused on improving the physical and mental health, and well-being of people within a specific geographical area or community.

Acute Care

Medical treatment that is short-term and typically for severe or urgent health conditions, often provided in hospitals or emergency departments.

Compassion Fatigue

Emotional distress or apathy resulting from the constant demands of caring for others, often experienced by healthcare professionals.

Palliative Care

Specialized medical care aimed at relieving pain and symptoms of serious illnesses, improving quality of life for both patient and family.