Interphase FISH Has Been Performed on a Patient Sample

question 21

Multiple Choice

Interphase FISH has been performed on a patient sample. With a chromosome 8 centromeric (CEP 8) probe, two signals are observed in each spread examined. A probe for the immunoglobulin heavy chain region on chromosome 14 gives two distinct signals per nucleus, and a probe for the myc gene on chromosome 8 gives two distinct signals per nucleus. Which of following interpretations is correct?

• A) The patient is normal.
• B) The patient has a t(14;8) translocation.
• C) The patient has a chromosome 8 deletion.
• D) The patient has a chromosome 8 insertion.

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Definitions:

Demand For Labor

The desire or need for employees by employers, determined by the wage rate and the level of production required by the firm or economy.

Price Floor

A government or regulatory-imposed minimum price for a good or service, intended to ensure that the market price does not fall below a certain level.

Surplus

The amount of a product or resource that exceeds the amount actually utilized or demanded.

Binding Minimum Wage

A government-set minimum wage that is above the equilibrium wage, potentially leading to unemployment because the quantity of labor supplied exceeds the quantity demanded.