A Genetic Variation in How the Metabolite of the Cancer

question 1

Multiple Choice

A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to:

• A) Decreased effectiveness of irinotecan in the treatment of cancer
• B) Increased adverse drug reactions, such as neutropenia
• C) Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
• D) Increased concerns for irinotecan being carcinogenic

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