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Scenario I
The following scenario is based on and presents fabricated data consistent with the following study:
Caspi,A. ,Sugden,K. ,Moffitt,T.E. ,Taylor,A. ,Craig,I.W. ,Harrington,H. ,McClay,J. ,Mill,J. ,Martin,J. ,Braithwaite,A. ,and Poulton,R.(2003) .Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene.Science,301(5631) ,386-389.
The serotonin transporter gene codes for the serotonin transporter,a protein that transports serotonin from the synapse to the presynaptic neuron.Several polymorphisms of the gene exist,including a "short" (s) and a "long" (l) variation.As humans receive one copy of the gene from each parent,people can be grouped into three groups based on this genetic variation: s/s (two copies of the short gene) ,s/l,and l/l.Caspi et al.(2003) interviewed participants in each of these groups and asked them a wide range of questions to determine both the degree of exposure to stress and the number of depressive episodes participants had experienced in their lives.Fabricated results consistent with their major findings are shown in Figure 3.1.
Figure 3.1
-(Scenario I) The function of the serotonin transporter protein is to:
Standard Deviation
A measure of the amount of variation or dispersion of a set of values. It quantifies how spread out the numbers are.
Empirical Rule
A statistical rule stating that for a normal distribution, nearly all data will fall within three standard deviations of the mean.
Bell-Shaped
Describes the graphical form of a distribution that is symmetric around its mean, visually represented as a bell-shaped curve, typically associated with the normal distribution.
Sample Standard Deviation
A measure of the dispersion or variability of a sample dataset, indicating how much the individual data points differ from the sample mean.
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