The Appropriate Sequence for Ubiquitination of Proteins to Be Degraded

question 6

Multiple Choice

The appropriate sequence for ubiquitination of proteins to be degraded is:
A.multiple ubiquitinations may occur on a protein substrate,
B.ubiquitin-protein ligase (E₃) transfers ubiquitin to free amino groups on the protein,
C.E₃ selects a protein for degradation by the nature of the N-terminal amino acid,
D.ubiquitin-carrier protein (E₂) picks up ubiquitin,
E.ubiquitin-activating enzyme (E₁) attaches via ATP-dependent formation of thioester bond to C-termini of ubiquitin,

• A) A, C, B, D, E
• B) E, D, A, B, C
• C) D, E, C, A, B
• D) C, E, D, B, A
• E) E, D, C, B, A

---

Definitions:

Volcanic Eruption

The process in which magma, ash, and gases are expelled from a volcano's vent, often dramatically affecting the surrounding environment.

Probability Calculus

A branch of mathematics that deals with calculating the likelihood of diverse outcomes, based on known parameters or prior probabilities.

Disjunction

A logical operation yielding a true statement when at least one of its component statements is true.

Notation P(B\A)

In probability, the notation representing the conditional probability of event B given that event A has occurred.