If Patients with Advanced CML Are Initially Treated with Gleevec,they

question 12

Multiple Choice

If patients with advanced CML are initially treated with Gleevec,they generally develop resistance to the drug within a few months.What seems to cause the resistance?

• A)mutations in the BCR portion of the fusion gene
• B)mutations in the ABL portion of the fusion gene
• C)ABL gene deletion
• D)ABL gene amplification
• E)BCR gene amplification

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Definitions:

Synaptic Cleft

Space between the presynaptic and the postsynaptic membranes.

Postsynaptic Membrane

The part of the cell membrane of a neuron that is on the receiving end of a synapse, where neurotransmitter receptors are located.

Excitatory Postsynaptic Potential

A temporary increase in synaptic potential that makes a post-synaptic neuron more likely to generate an action potential.

Hyperpolarized

A state in which a cell's membrane potential is more negative than its normal resting potential.