Why Does Targeting Glucocerebrosidase to Lysosomes in Macrophages Serve as a Treatment

question 51

Multiple Choice

Why does targeting glucocerebrosidase to lysosomes in macrophages serve as a treatment for Gaucher's disease?

• A)Glucocerebrosidase is normally denatured in the lysosomes.
• B)Glucocerebrosidase is delivered to the precise sites in the cell where the deficiency is manifested,thus correcting the deficit.
• C)Glucocerebrosidase denatures the cytoplasm from its location in the lysosomes correcting the deficit.
• D)Glucocerebrosidase binds to the outer lysosome surface and breaks down glycogen in the cytoplasm.
• E)Glucocerbrosidase is supposed to digest most of the enzymes in the lysosome.

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Definitions:

Penfield

Refers to Wilder Penfield, a neurosurgeon who made significant contributions to the understanding of the brain's function, particularly in mapping the sensory and motor cortices.

Language-Expression Deficits

Difficulties in the ability to convey thoughts, ideas, or feelings through spoken, written, or nonverbal language.

Wernicke's Aphasia

A form of aphasia characterized by fluent but meaningless speech and difficulty in understanding spoken words, often caused by damage to the posterior section of the temporal lobe.

Comprehension

The ability to understand and internalize the meaning of information, such as spoken or written language, symbols, or concepts.