CTLA-4,expressed by Regulatory T Cells and Activated Effector T Cells,is

question 10

Multiple Choice

CTLA-4,expressed by regulatory T cells and activated effector T cells,is crucial for self-tolerance as well as regulation of T cell responses of foreign antigens.Which of the following is a property of CTLA-4 that is important for its function?

• A)CTLA-4 binds to CD28 and blocks its function.
• B)CTLA-4 binds B7-1 and B7-2 with high affinity blocking their binding to CD28.
• C)CTLA-4 binds class I MHC and blocks it ability to bind peptides.
• D)CTLA-4 binds IL-2,preventing IL-2 binding to the IL-2 receptor.
• E)CTLA-4 binds to IgG,preventing IgG biding to antigens.

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Definitions:

Regression Model

A statistical technique used to predict the value of a dependent variable based on one or more independent variables.

Odds Ratio

A statistic that quantifies the strength of the association between two events, comparing the odds of an event occurring in one group to the odds of it occurring in another group.

Probability

A mathematical measure of the likelihood that an event will occur, often expressed as a number between 0 and 1.

Dependent Variable

A variable in an experiment or study that is dependent on other variables, typically the outcome or effect being measured.