Abatacept Is a Biologic Drug That Is a Fusion Protein

question 15

Multiple Choice

Abatacept is a biologic drug that is a fusion protein formed from the B7-binding domain of CTLA-4 fused to the human IgG1 constant region. In patients suffering from rheumatoid arthritis (RA) , high levels of granzyme B in the synovial fluid of inflamed joints is thought to contribute to joint erosion. When treated with abatacept, a subset of patients shows significant improvement in their RA symptoms together with decreased levels of granzyme B in their affected joints. These data indicate that the granzyme B found in RA patients' inflamed joints is predominantly made by:

• A) Antigen-presenting cells such as dendritic cells
• B) Activated macrophages
• C) Effector T cells
• D) FoxP3+ T_reg cells
• E) Neutrophils

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