Antibodies That Bind with High Affinity to Some Viral Surface

question 9

Multiple Choice

Antibodies that bind with high affinity to some viral surface proteins require heavy chain CDR3 loops of unusual length. Whereas the average human heavy chain CDR3 length is ~15 amino acids, antibodies with V_H CDR3 loops of >30 amino acids are readily detected in the repertoire. These antibody heavy chains with CDR3 lengths of >30 amino acids would likely be missing in individuals lacking:

• A) RAG-1 and RAG-2
• B) DNA-dependent protein kinase (DNA-PK)
• C) The nuclease, Artemis
• D) The Ku70:Ku80 complex
• E) Terminal deoxy nucleotidyl transferase (TdT)

Grasp the effect of sample size changes on standard error and sampling distribution properties.

Apply knowledge of normal distributions in practical sampling scenarios.

Evaluate conditions under which approximations to normality in sampling distributions apply.

Relate the principle of the finite population correction to the concept of a large population relative to sample size.

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Definitions:

Taboos

Social or cultural prohibitions or restrictions on certain behaviors, practices, or discussions, often considered sacred or forbidden.

Postmodern Condition

A term describing the societal state or cultural dynamics in which traditional norms and structures are questioned or rejected, emphasizing skepticism and relativism.

Consensus Building

A process or method aimed at achieving agreement or accord among group members or different stakeholders.

Democratic Process

A system of government by the whole population or all the eligible members of a state, typically through elected representatives.