Alefacept Is a Fusion Protein That Contains the CD2-Binding Domain

question 34

Multiple Choice

Alefacept is a fusion protein that contains the CD2-binding domain of LFA3 fused to human IgG1, and it is used to block CD2 function on human T cells. In addition, following in vivo administration, alefacept was also shown to deplete T cells of the effector or memory subsets that express high levels of CD2. Surprisingly, clinical trials data indicated that patients on alefacept still retained responses to vaccination. For example, one set of data showed that patients on alefacept made similar responses as the control group to a vaccine designed to protect against pneumococcal disease, which is composed entirely of bacterial polysaccharide antigens (pneumococcal polysaccharide vaccine; PPV) . This normal response to PPV by patients on alefacept is not surprising because:

• A) Alefacept is not very effective at blocking T cell responses.
• B) CD2 is not required for all T cell responses to vaccination.
• C) Alefacept does not deplete all effector or memory T cells, just a subset.
• D) T cells are involved in responses to polysaccharide antigens.
• E) The PPV was eliciting a recall response in previously exposed individuals.

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Definitions:

Fixed Costs

Expenses that do not change with production volume, remaining constant regardless of business activity level.

Relevant Range

The span of activity or volume in which the assumptions about fixed and variable cost behavior remain valid.

Variable Cost

A cost that changes in direct proportion to changes in the level of production or sales volume.

Total Fixed Cost

The sum of all constant expenses that a company incurs, regardless of the manufacturing or sales volume.