Studies in Mice Have Revealed Important Features About Some Chronic

question 10

Multiple Choice

Studies in mice have revealed important features about some chronic infections. In the case of mice infected with a persistent strain of lymphocytic choriomeningitis virus (LCMV) , these studies showed that a majority of the virus-specific T cells were eliminated from the mice over time; however, some virus-specific CD8 T cells persisted but were unable to eradicate the viral infection. These remaining cells expressed high levels of several inhibitory receptors, including PD-1. One possible treatment for these mice to promote their ability to clear this chronic infection would be:

• A) Immunization with an inactivated preparation of LCMV
• B) Administration of anti-PD-1 antibody
• C) Administration of an antiviral drug that would block LCMV replication
• D) Immunization with a purified surface antigen from LCMV
• E) Stimulation with a TLR7 or TLR9 ligand to induce an interferon response

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