Cyclosporin a and Rapamycin Are Each Used as T Cell

question 19

Multiple Choice

Cyclosporin A and rapamycin are each used as T cell immunosuppressants. They share the property of binding to immunophilin molecules in T cells as the initial step in their mechanisms of action. However, in the case of cyclosporin A, the drug:immunophilin complex binds to and inhibits the protein phosphatase calcineurin, whereas the rapamycin:immunophilin complex binds to and inhibitors mTOR. As a consequence,

• A) Cyclosporin A, but not rapamycin, blocks cytokine production by T cells.
• B) Both cyclosporin A and rapamycin block cytokine production by T cells.
• C) Rapamycin, but not cyclosporin A, blocks T cell proliferation.
• D) Neither rapamycin nor cyclosporin A block T cell proliferation.
• E) Both cyclosporin A and rapamycin inhibit co-stimulatory signaling through CD28 on T cells.

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