Due to Its Multiple Roles in Promoting Inflammatory Responses, the Complement

question 12

Multiple Choice

Due to its multiple roles in promoting inflammatory responses, the complement system has been a target for the development of compounds that interfere with the complement system as a means of treating chronic autoimmune diseases. While some compounds inhibit the formation of the membrane attack complex, others are aimed at inhibiting earlier steps in the complement cascade. One such compound is an inhibitor of the C5a receptor, a receptor expressed on macrophages, dendritic cells, and granulocytes. The C5a receptor inhibitor would function to:

• A) Prevent the recruitment of macrophages and neutrophils to the sites of autoantibody binding
• B) Prevent cell lysis by the membrane attack complex
• C) Prevent cell uptake by phagocytic cells bearing complement receptors
• D) Enhance the binding of IVIG to the low affinity Fc receptor on phagocytes
• E) Prevent the binding of autoantibodies to activating Fc receptors

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Definitions:

Differentiation

The process or strategy of making a product, service, or brand stand out as unique from competitors, often through design, features, or quality.

Organic Structures

An organizational form that is flat, uses low levels of formalization, and fosters the sharing of knowledge and power across levels, promoting flexibility and quick response to changes.

Span of Control

The number of subordinates that a manager or leader can efficiently manage and oversee.

Centralisation

Centralisation is the concentration of authority for most decisions at the top level of an organisation.