In the Late 1990s, Compounds That Functioned as Leukotriene Receptor

question 9

Multiple Choice

In the late 1990s, compounds that functioned as leukotriene receptor antagonists were approved for the treatment of asthma. The first such drug, zafirlukast, inhibits the actions of a major receptor for leukotrienes, known as CYSLTR1 (cysteinyl leukotriene receptor 1) . One would predict that patients on this drug would show:

• A) Enhanced mucus production
• B) Enhanced vascular permeability
• C) Increased accumulation of leukocytes in the lung
• D) Reduced mast cell activation
• E) Reduced bronchoconstriction

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