Individuals That Lack All T Cells Have the Most Severe

question 17

Multiple Choice

Individuals that lack all T cells have the most severe form of immunodeficiency (SCID) and will not survive past their first birthday without a bone marrow transplant from a healthy donor. These individuals fail to make antibody responses to the normal childhood vaccines because:

• A) They generally lack all B cells
• B) SCID causes a defect in B-cell receptor signaling
• C) SCID patients lack AID, so their B cells cannot undergo class switching
• D) Most antibody responses require T cell help for the B cells
• E) Persistent infections in SCID infants disrupts hematopoiesis

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