Studies Have Shown That Secondary Lymphoid Tissues Are a Major

question 18

Multiple Choice

Studies have shown that secondary lymphoid tissues are a major reservoir of HIV in infected individuals. In part, this is due to the high numbers of viral target cells expressing CD4, such as T cells, macrophages, and dendritic cells. Surprisingly, secondary lymphoid tissues were also found to contain large numbers of infectious virus particles in the form of immune complexes. A comparison of the viral species found in these immune complexes indicates that they include virus particles that have been retained for over a year. The cells responsible for this reservoir of infectious HIV are:

• A) HIV-specific B cells
• B) Follicular dendritic cells
• C) CD4 T cells
• D) Subcapsular sinus macrophages
• E) CD4⁺ dendritic cells

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Definitions:

Protons

Positively charged subatomic particles found within the nucleus of an atom.

Electrons

Subatomic particles with a negative charge, orbiting the nucleus of an atom.

Charged Atom

A charged atom, also known as an ion, is an atom that has gained or lost one or more electrons, resulting in a positive or negative charge.