Unlike Defects in Antibodies or T Cell Functions, Defects in Complement

question 12

Multiple Choice

Unlike defects in antibodies or T cell functions, defects in complement components often lead to autoimmune-like symptoms, rather than to increased susceptibility to infections. This is because:

• A) Complement components do not require antibodies to attack microbial pathogens.
• B) The complement pathway normally functions to clear immune complexes from the circulation.
• C) Complement inhibitory proteins are up-regulated by complement activation.
• D) The complement pathway is part of the innate, rather than the adaptive immune response.
• E) Partial activation of the complement cascade promotes phagocytosis of host cells.

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