Scaffold Proteins Are Often Phosphorylated at Multiple Sites, Allowing the Recruitment

question 22

Multiple Choice

Scaffold proteins are often phosphorylated at multiple sites, allowing the recruitment of several different signaling proteins. In antigen receptor signaling pathways, this mechanism is used to bring enzymes in close proximity to their substrates. Termination of this signaling mechanism would be most efficiently accomplished by:

• A) Ubiquitination of the scaffold protein, leading to its degradation
• B) Binding of the enzyme to a GTPase activating protein (GAP)
• C) Depletion of the substrate due to enzyme catalysis
• D) Dephosphorylation of the scaffold by a phosphatase
• E) Ubiquitination of the enzyme by K63-linkage of polyubiquitin

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