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One HIV Vaccine Trial Provided Some Small Measure of Hope

question 14

Multiple Choice

One HIV vaccine trial provided some small measure of hope for the development of an effective HIV vaccine. This vaccine, known as RV144, was administered to a high risk population in Thailand, and reduced new infections by ~30%. To address the mechanism of immune protection correlating with vaccine efficacy, a series of studies were performed. In one study, total IgG antibodies from four non-infected vaccinees were isolated and were mixed with HIV-infected cells plus peripheral blood lymphocytes from healthy unrelated donors. As a control, IgG antibodies were purified from four donors receiving the placebo, rather than the RV144 vaccine. Six hours later, lysis of the HIV-infected target cells was assessed, as shown in Figure Q40) . Figure Q40) The immune mechanism that correlates with protection based on these data is:

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Definitions:

Major Depression

A mental disorder characterized by persistent sadness, lack of interest in activities, and other symptoms that impair daily functioning.

Cognitive Distortion

Irrational, faulty thinking patterns that contribute to emotional distress and mental health disorders.

Dichotomy

A division or contrast between two things that are presented as entirely different or opposite.

All-Or-None Thinking

A cognitive distortion involving viewing situations in only two categories instead of on a continuum, such as completely right or completely wrong.